Davit T․ Babikyan

Associate Professor, Department of Medical Genetics, Yerevan State Medical University after Mkhitar Heratsi

Head of the Laboratory of Molecular Genetics, Center of Medical Genetics and Primary Health Care

PhD researcher, International Center for Cancer Research, Lyon, France

Researcher, Medical Genetics Center of NAS RA, Yerevan, Armenia

Junior Researcher, Institute of Molecular Medicine, Huntington Beach, California, USA

Moradian MM, Babikyan D, Banoian D, Hayrapetyan H, Manvelyan H, Avanesian N, Sarkisian T. Comprehensive analysis of mutations in the MEFV gene reveal that the location and not the substitution type determines symptom severity in FMF. Mol Genet Genomic Med. 2017 Nov;5(6):742-750

Բաբիկյան Դ. Քաղցկեղի կլինիկական գենետիկա. Ուսումնամեթոդական ձեռնարկ. ԵՊԲՀ. 2017

Babikyan D. The Utility of Sufficiently Informative Protein Multiple Sequence Alignment For Cancer Risk Assessment of BRCA2 Missense Substitutions. Biological Journal of Armenia, 4(68) 76-80, 2016

Babikyan D. High-Resolution Melt Curve Analysis as a High-Throughput screening method of large genes (տպագրության մեջ)

Babikyan D, Zakharyan A. Role of genetic diagnosis for patients with suspicion of thalassemia intermediate/minor. EHA Learning Center. Jun 9, 2016; 135019

Melik-Pashayan, Andryushenko, Babikyan, Mironova, Aghekyan. Genetic markers of depression recurrence in Russian and Armenian population. The New Armenian Medical Journal, Yerevan 2015. 9 (3): 107

Бабикян Д.Т. Глава. Генетика мужского бесплодия. 388-409. Книга. Мужское Здоровье. Мурадян А.А. Ереван 2015

D. Babikyan, S. Midyan, A. Hovhannisyan, A. Gasparyan, T. Sarkisian. De novo single exon deletion of AUTS2 in a patient with profound intellectual disability. Eur. J Hum. Genet. 2014 May 22:151

Դ.Թ. Բաբիկյան, Ս.Ա. Միդյան, Ա.Հ. Հովհաննիսյան, Հ.Ս. Մկրտչյան, Ա.Վ. Գասպարյան, Ջ. Հեթինգեր, Ա.Կուրգ, Ֆ. Պատսալիս, Թ.Ֆ. Սարգսյան 1q21.3 քրոմսոսմային հատվածի միկրոդուպլիկացիան որպես մտավոր հետամնացության նոր գենետիկական պատճառ. ԵՊԲՀ հաշվետու տարեկան գիտաժողով-2013: Գիտական հոդվածների ժողովածու, Երևան 2013, Հատոր1. 251-257

D Babikyan, I Jeru, B Copin, H Hayrapetyan, S Amselem, T Sarkisian. FMF-like state: genetic factors unrelated to MEFV. Pediatric Rheumatology 2013, 11(Suppl 1):A85:29-30

D. T. Babikyan, H. Mkrtchyan, S. Midyan, M. Nõukas, K. Männik, A. Hovhannesyan, A. Gasparyan1, T. Liehr, A. Kurg, T. F. Sarkisian; Molecular cytogenetic characterization of a family with 3p deletion and 3p duplication cases Eur. J Hum. Genet. 2012 May 20:52

C. Graziano, E. Bonora, J. A. Hettinger, K. Männik, P. Magini, M. Badura-Stronka, E. Õiglane-Slik, J. Kasnauskienè, I. Lebedev, M. Havlovicova, D. Babikyan, L. A. Livshits, T. Sarkisian, A. Latos-Bieleńska, V. Kučinskas, Z. Sedlacek, P. C. Patsalis, A. Kurg, G. Romeo1. CHERISH - Improving Diagnoses of Mental Retardation in Children in Eastern Europe and Central Asia through Genetic Characterisation and Bioinformatics/Statistics - a GENOMIC PROJECT. Eur. J Hum. Genet. 2012 May 20:272-273

Vallée MP, Francy TC, Judkins MK, Babikyan D, Lesueur F, Gammon A, Goldgar DE, Couch FJ, Tavtigian SV Classification of Missense Substitutions in the BRCA Genes: a Database Dedicated to Ex-UVs. Hum Mutat. 2012 Jan;33(1):22-8

D. Babikyan, S. Midyan, K. Mannik, S. Parkel, A. Hovhannisyan, H. Mkrtchyan, A. Gasparyan, A. Kurg, T. Sarkisian. Use of SNP-array in a cohort of Armenian children with mental retardation. Eur. J Hum. Genet. 2011 May 19:136

A. Kurg, K. Männik, M. Nõukas, O. Zilina, E. Õiglane-Šlik1, C. Graziano, E. Bonora, P. Magini, J. Baptista, G. Tortora, S. Miccoli, P. C. Patsalis, J. A. Hettinger, V. Anastasiadou, V. Kučinskas, J. Kasnauskienè E. Preikšaitienė, I. Lebedev, A. Latos-Bieleńska, M. Badura-Stronka, S. Debicki, Z. Sedlacek, M. Havlovicova, M. Vlckova, M. Hancarova, T. Sarkisian, D. Babikyan, S. Midyan, L. A. Livshits, G. Romeo. CHERISH - Improving Diagnoses of Mental Retardation in Children in Eastern Europe and Central Asia through Genetic Characterisation and Bioinformatics/Statistics. 15th International Workshop on Fragile X and Early-Onset Cognitive Diseases, Berlin, Germany, September 4-7 2011

H. Puehringer, B. Rauscher, T.Sarkisian, K.Pagava, H.Hayrapetyan, D.Babikyan, I.Korinteli, M.Korinteli, C.Oberkanins. Thalassemia carrier screening in the transcaucasian countries Armenia and Georgia. 12th International Conference on Thalassaemia and other Haemoglobinopathies. May 2011, Abstract book, 55

Le Calvez-Kelm F, Lesueur F, Damiola F, Vallee M, Voegele C, Babikyan D, Durand G, Forey N, McKay-Chopin S, Robinot N, Nguyen-Dumont T, Thomas A, Byrnes GB, Breast Cancer Family Registry T, Hopper JL, Southey MC, Andrulis IL, John EM, Tavtigian SV. Rare, evolutionarily unlikely missense substitutions in CHEK2 contribute to breast cancer susceptibility: results from a breast cancer family registry (CFR) case-control mutation screening study. Breast Cancer Res. 2011 Jan 18;13(1):R6

C. Graziano, E. Bonora, P. Magini, J. Baptista, G. Tortora, S. Miccoli, K. Mannik, T. Sarkisian, D. Babikyan, S. Midyan, G. Romeo, etc. CHERISH- Improving Diagnoses of Mental Retardation in children in Eastern Europe and Central Asia through genetics characterization and Bioinformatics/Statistics. Eur. J. Hum. Genet. 2010 June 18:85

D. Babikyan, H. Hayrapetyan, T.Davtyan, T. Sarkisian. Existence of FMF-like condition unrelated to MEFV. Eur. J. Hum. Genet. 2010 June 18:318

Հակոբյան Ա., Սարգսյան Թ., Լյուլեջյան Կ., Միդյան Ս., Շահսուվարյան Գ., Բաբիկյան Դ. Մտավոր հետամնացության պատճառագիտությունը. Մարդու Առողջությունը VIII ազգային գիտաբժշկական կոնգրեսի նյութերի ժողովածու 2009: 288-289

Tavtigian SV, Oefner PJ, Babikyan D, Hartmann A, Healey S, Le Calvez-Kelm F, Lesueur F, Byrnes GB, Chuang SC, Forey N, Feuchtinger C, Gioia L, Hall J, Hashibe M, Herte B, McKay-Chopin S, Thomas A, Vallée MP, Voegele C, Webb PM, Whiteman DC; Australian Cancer Study; Breast Cancer Family Registries (BCFR); Kathleen Cuningham Foundation Consortium for Research into Familial Aspects of Breast Cancer (kConFab), Sangrajrang S, Hopper JL, Southey MC, Andrulis IL, John EM, Chenevix-Trench G. Rare, evolutionarily unlikely missense substitutions in ATM confer increased risk of breast cancer. Am J Hum Genet. 2009; 85(4):427-46

Babikyan DT, Sarkisian TF. Preliminary genetic investigation of high-risk breast cacner patients in Armenia. European Journal of Human Genetics 2009; 17:S2:191

Spurdle AB, Lakhani SR, Healey S, Parry S, Da Silva LM, Brinkworth R, Hopper JL, Brown MA, Babikyan D, Chenevix-Trench G, Tavtigian SV, Goldgar DE; kConFab Investigators. Clinical classification of BRCA1 and BRCA2 DNA sequence variants: the value of cytokeratin profiles and evolutionary analysis--a report from the kConFab Investigators. J Clin Oncol. 2008; 26(10):1657-63

D.T.Babikyan, F. Lesueur, C. Voegele, M. Hashibe, J. Hall, G.B. Byrnes, S.V.Tavtigian. Analysis of ATM case-control mutation screening data. European Journal of Human Genetics, 2008, 16:sup2, p218-219

D. Babikyan, F. Lesueur, C. Voegele, M. Vallee, F.Le Calvez-Kelm, M. Hashibe, C. Shu-Chun, J. Hall, G.B. Byrnes, S.V.Tavtigian. ATM in breast cancer susceptibility. European Journal of Cancer, 2008, 6:9, p11

Babikyan D. Comparative analysis of anti-amyloid b immune responses generated after different routes of immunizations with plasmid encoding Ab-peptide immunogen fused with IL4 Медицинская наука Армении. 2004. т. XLIV, ¨1, с. 62-68

Ghochikyan A, Vasilevko V, Petrushina I, Movsesyan N, Babikyan D, Tian W, Sadzikava N, Ross TM, Head E, Cribbs DH, Agadjanyan MG. Generation and characterization of the humoral immune response to DNA immunization with a chimeric beta-amyloid-interleukin-4 minigene Eur J Immunol. 2003 Dec; 33(12):3232-41

Cribbs D.H., Lees A., Ghochikyan A., Vasilevko V., Petrushina I., Movsesyan N., Babikyan D., Tran M., DeVolger A., Agadjanyan M. Mannan as a Molecular Adjuvant for A-Immunotherapy. 6th International Conference on Progress in Alzheimer’s and Parkinson’s Diseases. New Trends in Alzheimer and Parkinson Related Disorders. Seville (Spain), 2003, p 81-85

Cribbs D.H. Lees A., Ghochikyan A., Vasilevko V., Petrushina I., Movsesyan N., Babikyan D, Agadjanyan M.G. Th2 adjuvants and foreign T-cell epitopes for beta-amyloid immunotherapy. 33rd Annual Meeting of the Society for Neuroscience. New Orleans (USA), 2003

Cribbs DH, Ghochikyan A, Vasilevko V, Tran M, Petrushina I, Sadzikava N, Babikyan D, Kesslak P, Kieber-Emmons T, Cotman CW, Agadjanyan MG. Adjuvant-dependent modulation of Th1 and Th2 responses to immunization with beta-amyloid. Int Immunol. 2003 Apr; 15(4):505-14

Саркисян Т.Ф., Айрапетян А.С., Мнджоян Е.О., Оганесян З.Р., Бабикян Д.Т., Степанян Т.С. Перспективы ДНК-диагностики наследственной патологии на примере периодической болезни. Медицинская наука Армении. 2001, т. XLI, ¨ 2, с. 31-37

Babikyan D., Grigoryan T., Sarkisian T. Phenotype-genotyp correlations in Armenian patients with FMF. In: “8th Armenian Medical World Congress.- Canada, 2001, p. 8-9

Aйрапетян А.С., Мнджоян Е.О., Оганесян З.Р., Бегларян А.А., Степанян Т.С., Бабикян Д.Т., Григорян Т.С., САркисян Т.Ф.. Молекулярная диагностика периодической болезни среди армян. 2001, с. 11-15

Sarkisian T., Ajrapetyan H., Mndjoyan E., Oganesyan Z, Babikyan D. Molecular study of MEFV gene mutations in Armenians Genetic Susceptibility at low Dose Exposure: 31st Annual Meeting of the European Environmental Mutagen Society.Ghent (Belgium), 2001, p. 90

Բաբիկյան Դ. Գենոտիպի և ֆենոտիպի կորելացիաները պարբերական հիվանդների հայկական պոպուլյացիայում, Երիտ. գիտն. հոդվ. ժողով. Երևանի համալս. Հրատ., 2000, հ.2, էջ 84-87

"Laboratory Diagnosis of Medical Genetics", Conference of European Society of Human Genetics and European Clinical Laboratory Genetics Company, Athens, Greece

ESHG 2017 Conference, Copenhagen, Denmark

ESHG 2016 conference, Barcelona, Spain

ESHG 2014 Conference, Milan, Italy

ESHG 2013 Conference, Paris, France

International Conference on Auto-inflammatory Diseases, Lausanne, Switzerland

Meeting of European Association for Cancer Research (EACR21), Barcelona, Spain

ESHG 2011 Conference, Amsterdam, The Netherlands

International Conference on Auto-inflammatory Diseases, Amsterdam, The Netherlands

ESHG 2010 Conference, Gofenberg, Sweden

PARTICIPATION IN INTERNATIONAL SCIENTIFIC PROGRAMS:

Project Manager of A2151 International Science and Technology Center (ISTC) Program "Nuclear and mitochondrial genetic variants and molecular bases of mitochondrial OXPHOS diseases"

Project Manager of EU Tempus MedGen Program "Developing Medical Genetics Education through Curriculum Reforms and Establishment of Postgraduate Training Programs"

Project Manager of EU FP7-INCO INARMERA Program “INTEGRATING ARMENIA INTO ERA”

Participant of EU FP7-HEALTH CHERISH Program “Improving Diagnoses of Mental Retardation in Children in Eastern Europe and Central Asia through Genetic Characterization and Bioinformatics/Statistics”

Project Manager of A1580 International Science and Technology Center (ISTC) Program “Molecular basis of the autoinflammation developed in FMF and related disorders”

ORGANIZATION OF CONFERENCES:

"National Medical Genetics Day" International Conference, Yerevan, Armenia

"Autoinflammatory Disorder" International Conference, Yerevan, Armenia

"MedGen: genetic health and genetic education" International Conference, Yerevan, Armenia

“Modern Genetics in health Care system” International Conference, Yerevan, Armenia

Member of European Society of Human Genetics (ESHG)

Member of Armenian Association of Human Genetics

Member of European Association for Cancer Research (EACR)